Napoli have to win in order to retain their Serie A leadership status, but are decimated by injuries as they host on-form Atalanta.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
Serie A Liveblog: Milan-Salernitana, Roma-Inter, Napoli-Atalanta
The Partenopei are under huge pressure, because Milan already won and Inter too leapfrogged them at the top of the table.
However, Luciano Spalletti is down to the bare bones, as long-term absentees Victor Osimhen and Andre-Frank Zambo Anguissa have been joined on the treatment table by Kalidou Koulibaly – out for at least a month – Lorenzo Insigne and Fabian Ruiz.
Kostas Manolas isn’t fully fit either, so Juan Jesus has to step in at centre-back and it seems to be a 3-4-3 formation for the first time this season.
Dries Mertens is the centre-forward, with Eljif Elmas and Chucky Lozano in the trident attack.
Atalanta rotated their squad for the midweek demolition of Venezia and earned a 1-0 win away to Juventus last week, consolidating their Scudetto credentials.
Robin Gosens and Matteo Lovato are the only absentees, as Duvan Zapata is joined by Ruslan Malinovskyi and Matteo Pessina upfront.
Napoli: Ospina; Di Lorenzo, Rrahmani, Juan Jesus; Malcuit, Zielinski, Lobotka, Mario Rui; Elmas, Mertens, Lozano
Atalanta: Musso; Toloi, Demiral, Palomino; Zappacosta, De Roon, Freuler, Maehle; Pessina; Malinovskyi, Duvan Zapata