Milan look to Zlatan Ibrahimovic and Rafael Leao against former Inter midfielder Thiago Motta’s Spezia.
It kicks off at 17.30 UK time.
Stefano Pioli has picked the Swede over Olivier Giroud, while Rafael Leao and Theo Hernandez start on the left.
Milan are short of options in midfield and defence.
Alessio Romagnoli had a negative swab test today but will return to group training tomorrow so Pierre Kalulu and Matteo Gabbia start in central defence as Fikayo Tomori and Simon Kjaer are both injured.
Rade Krunic and Tiemoue Bakayoko start in midfield with Sandro Tonali is suspended and Franck Kessié is on Africa International duty.
Kevin Agudelo returns to action for Spezia but starts from the bench. Thiago Motta can rely on full squad.
Spezia won the last two away games without conceding. They had won five of their previous 28, keeping just three clean sheets.
Line-ups:
Milan (4-2-3-1): Maignan; Florenzi, Kalulu, Gabbia, Hernandez; Krunic, Bakayoko; Saelemaekers, Diaz, Leao; Ibrahimovic.
Spezia (4-4-1-1): Provedel; Amian, Erlic, Nikolaou, Reca; Maggiore, Kiwior, Bastoni, Gyasi; Verde; Manaj.