Milan rotate the squad against Salernitana, who have Franck Ribery back in the side, looking to Pietro Pellegri, Brahim Diaz and Rafael Leao.
It kicks off at San Siro at 14.00 GMT.
You can follow all the build-up and action as it happens from this game, Roma–Inter and Napoli–Atalanta on the LIVEBLOG.
The Rossoneri have closed the gap on leaders Napoli to just one point and have by far the simplest fixture on paper for this weekend of the Scudetto contenders.
However, they also lost Simon Kjaer for the rest of the season, with Olivier Giroud, Ante Rebic, Samu Castillejo and Davide Calabria still out injured.
Zlatan Ibrahimovic is rested, so Pellegri gets his first start, amid reports he’ll be returned early in January from his Monaco loan spell.
Alessio Romagnoli is back from suspension to bolster the defence.
Salernitana have Ribery back in the side and the starting XI partnering Nwankwo Simy in attack.
They too have issues in defence, missing Strandberg after hernia surgery and Riccardo Gagliolo with a stomach bug, joining long-term absentee Mamadou Coulibaly.
Milan: Maignan; Florenzi, Tomori, Romagnoli, Theo Hernandez; Kessiè, Bakayoko; Saelemaekers, Brahim Diaz, Leao; Pellegri
Salernitana: Belec; Bogdan, Gyomber, Veseli; Zortea, L. Coulibaly, Di Tacchio, Schiavone, Ranieri; Ribery, Simy.