It kicks off at San Siro at 17.00 UK time (16.00 GMT).
Both these teams have started the season with a perfect record and plenty of goals, particularly Maurizio Sarri’s men after thrashing Spezia 6-1.
That makes it an early potential title clash and a meeting between two of the most attack-minded sides in the league.
Kessie is back after his injury and goes straight into the starting XI, but Olivier Giroud is left out after recovering from COVID-19 and Rade Krunic is injured. Zlatan Ibrahimovic is on the bench and is expected to get some playing time in the second half.
Milan: Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Tonali, Kessie; Florenzi, Brahim Diaz, Leao; Rebic