Franck Kessie returns to the starting XI for Milan, while Lazio look to Ciro Immobile and Felipe Anderson in this top of the table battle.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
Both these teams have started the season with a perfect record and plenty of goals, particularly Maurizio Sarri’s men after thrashing Spezia 6-1.
That makes it an early potential title clash and a meeting between two of the most attack-minded sides in the league.
Kessie is back after his injury and goes straight into the starting XI, but Olivier Giroud is left out after recovering from COVID-19 and Rade Krunic is injured. Zlatan Ibrahimovic is on the bench and is expected to get some playing time in the second half.
Lazio are missing only Bobby Adekanye, as Manuel Lazzari returns to the bench following a calf issue.
Ciro Immobile leads the trident with Pedro and Felipe Anderson, plus Luis Alberto and Sergej Milinkovic-Savic in midfield.
Milan: Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Tonali, Kessie; Florenzi, Brahim Diaz, Leao; Rebic
Lazio: Reina; Marusic, Luiz Felipe, Acerbi, Hysaj; Milinkovic-Savic, Leiva, Luis Alberto; Pedro, Immobile, Felipe Anderson
C’mon Lazio!
Forza Milan