Milan look to Zlatan Ibrahimovic, Rafael Leao and Junior Messias, while Juventus rely on Paulo Dybala, Alvaro Morata and Weston McKennie in this San Siro showdown, but lose Matthijs de Ligt.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
Liveblog: Serie A Wk23 inc Napoli-Salernitana, Empoli-Roma, Milan-Juventus
This represents not only one of the classic fixtures in Italian football between age-old rivals, but also a huge game for the table.
Milan’s controversial 2-1 home defeat to Spezia saw them fall behind leaders Inter and Napoli today leapfrogged them into second place.
If Juve win, they will climb into the top four above Atalanta and be within four points of the Rossoneri.
Fikayo Tomori, Simon Kjaer and Pietro Pellegri are still injured, with Franck Kessie and Fode Ballo-Toure at the Africa Cup of Nations.
There are some returns for Stefano Pioli, as Alessio Romagnoli has shaken off COVID to start, Sandro Tonali is back after suspension and Ismael Bennacer is available on the bench after Algeria’s early AFCON elimination.
Ibrahimovic leads the way with support from Leao, Brahim Diaz and Messias.
Juventus miss Leonardo Bonucci and Federico Chiesa, while Aaron Ramsey is by now on his way out.
Manuel Locatelli and Mattia De Sciglio face their former club, with Dybala and McKennie joining Morata.
Matthijs de Ligt is only on the bench, as he had a stomach bug over the last few days and is debilitated.
Milan: Maignan; Calabria, Kalulu, Romagnoli, Theo Hernandez; Tonali, Krunic; Messias, Brahim Diaz, Leao; Ibrahimovic
Juventus: Szczesny; De Sciglio, Rugani, Chiellini, Alex Sandro; Cuadrado, Bentancur, Locatelli, McKennie; Dybala, Morata
Its nice to not see rabiot but all defence line is so weak… So so bad choices all 4…
What the Krunic? Oh well, better him than Bakayoko.
Juvebdefence should been totaly different pellegrini bonnuci de ligt danilo, or cuadrado and arthur on field… Such stupid Allegris choice can cost really much