Olivier Giroud and Brahim Diaz again lead the way for Milan as they try to maintain a 100 per cent record against Cagliari.
It kicks off at the Stadio Giuseppe Meazza, in the San Siro neighbourhood of Milan, at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from today’s four Serie A games on the LIVEBLOG.
The Rossoneri opened their campaign with a 1-0 win away to Sampdoria and are still missing Zlatan Ibrahimovic, Franck Kessie and new signing Pietro Pellegri.
Giroud is therefore the centre-forward, supported by Brahim Diaz, Alexis Saelemaekers and Rafael Leao.
Once again, Rade Krunic gets the nod rather than Ismael Bennacer with Sandro Tonali in midfield.
Cagliari fought back from 2-0 down to draw 2-2 with Spezia last week, but lost goalkeeper Alessio Cragno to injury.
Boris Radunovic therefore takes the gloves, with Luca Ceppitelli returning in defence and Joao Pedro partnering Leonardo Pavoletti upfront.
Milan: Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Krunic, Tonali; Saelemaekers, Brahim Diaz, Leao; Giroud
Cagliari: Radunovic; Ceppitelli, Godin, Carboni; Nandez, Marin, Strootman, Deiola, Dalbert; Joao Pedro, Pavoletti