Lazio make changes in defence and trust in Ciro Immobile to get them back on track against an Udinese side who use Beto and Isaac Success upfront.
It kicks off at the Stadio Olimpico at 19.45 GMT.
Maurizio Sarri is under pressure after a 4-0 defeat to his former club Napoli, but is forced into some changes because Luiz Felipe is suspended.
Patric therefore steps into centre-back, as Manuel Lazzari is drafted in to play at right-back.
Immobile is flanked by Felipe Anderson and Pedro again, with Sergej Milinkovic-Savic and Luis Alberto in midfield.
Udinese have decided to stick with coach Luca Gotti for the moment, but the run of poor results is becoming an issue, especially after a 0-0 draw with Genoa.
It’s a special game for him, because Gotti was Sarri’s assistant manager at Chelsea.
Roberto Pereyra went off during that game with a dislocated clavicle and will be out until the New Year.
Beto is therefore supported by Gerard Deulofeu and Success in a new 4-4-2 formation.
Lazio: Reina; Lazzari, Patric, Acerbi, Hysaj; Milinkovic-Savic, Cataldi, Luis Alberto; Felipe Anderson, Immobile, Pedro
Udinese: Silvestri; Perez, Becao, Samir, Udogie; Molina, Walace, Jajalo, Deulofeu; Success, Beto