It’s a fascinating Derby della Capitale between Maurizio Sarri’s Lazio and Jose Mourinho’s Roma, with Ciro Immobile, Tammy Abraham, Pedro and Nicolò Zaniolo starting.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
This fixture is always passionate, fiery and controversial, even more so now it has two coaches making their debuts in the Rome Derby.
Sarri and Mourinho have already clashed before in the Premier League and have had very different starts to their Capital careers, Mou winning all but one of his competitive games so far and Sarri scraping two draws from his last four.
Mattia Zaccagni is injured, so Pedro starts against his former club with Felipe Anderson, Immobile, Sergej Milinkovic-Savic and Luis Alberto.
Roma have Matias Vina back from injury at left-back, but captain Lorenzo Pellegrini is suspended following his harsh second yellow card against Udinese.
Stephan El Shaarawy is chosen to fill in, with Henrikh Mkhitaryan, Zaniolo and Abraham.
Despite the fact he is unavailable, Pellegrini still spent the day with his teammates and travelled to the stadium on their bus.
Lazio: Reina; Marusic, Luiz Felipe, Acerbi, Hysaj; Milinkovic-Savic, Leiva, Luis Alberto; Pedro, Immobile, Felipe Anderson
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Mkhitaryan, El Shaarawy; Abraham