Ciro Immobile, Luis Alberto and Sergej Milinkovic-Savic start for Maurizio Sarri’s Lazio against Victor Osimhen, Lorenzo Insigne and Piotr Zielinski, as Napoli try to go joint top of the Serie A table.
It kicks off at the Stadio Olimpico at 19.50 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Serie A Liveblog: Torino-Cagliari, Verona-Venezia, Spezia-Roma, Lazio-Napoli
The last time Napoli got this close to a Scudetto run was under Sarri’s tenure, but now he is standing in their way and seeking points to qualify for Europe instead.
Luis Alberto and Lucas Leiva are back after they were suspended against Udinese, while Immobile has recovered from flu to face his hometown club.
Milinkovic-Savic also pulls the midfield strings, with Felipe Anderson and Mattia Zaccagni upfront, as Pedro is not at 100 per cent.
It’s a reunion also for Elseid Hysaj and former Napoli goalkeeper Pepe Reina, although they are on the bench.
As for the Partenopei, Hirving Lozano, Andre-Frank Zambo Anguissa and Axel Tuanzebe are still out of action, with Kevin Malcuit carrying a knock.
Osimhen leads the attack with Insigne, Zielinski and Matteo Politano.
Lazio: Strakosha; Marusic, Luiz Felipe, Patric, Radu; Milinkovic-Savic, Leiva, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Demme, Fabian Ruiz; Politano, Zielinski, Insigne; Osimhen