Lazio must do without Ciro Immobile, so Pedro goes into a False 9 role and Sergej Milinkovic-Savic returns against a Genoa with Mattia Destro back upfront.
It kicks off at the Stadio Olimpico at 17.30 GMT.
The Biancocelesti have been stuttering under Maurizio Sarri and the pressure will be on to win this game against relegation contenders Genoa.
However, star striker Immobile is out with a stomach bug, so rather than use Vedat Muriqi, Sarri is instead again using Pedro as a False 9.
Milinkovic-Savic returns from suspension and Luis Alberto is available again after injury.
Andriy Shevchenko got his first win on the Genoa bench this week, beating Salernitana 1-0 in the Coppa Italia, but it has been 11 rounds since the team’s last Serie A victory.
The good news is Destro is available from the start after over a month out, but ex-Lazio players Felipe Caicedo and Mohamed Fares are on the injury list along with Nicolò Rovella and Nikola Maksimovic.
Lazio: Strakosha; Hysaj, Luiz Felipe, Acerbi, Marusic; Milinkovic-Savic, Cataldi, Basic; Felipe Anderson, Pedro, Zaccagni
Genoa: Sirigu; Vanheusden, Vasquez, Criscito; Ghiglione, Sturaro, Badelj, Portanova, Cambiaso; Pandev, Destro