Paulo Dybala, Moise Kean and Dejan Kulusevski start for Juventus against a decimated Udinese who look to Beto and Gerard Deulofeu.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
The Bianconeri are still smarting after Wednesday’s 2-1 Supercoppa Italiana defeat to Inter, decided by Alexis Sanchez in the final seconds of extra time.
Leonardo Bonucci, Danilo, Federico Chiesa and Aaron Ramsey are out of action, with Alvaro Morata not 100 per cent fit.
Moise Kean therefore starts upfront with Dybala and Kulusevski, while Juan Cuadrado and Matthijs de Ligt return after their Supercoppa bans.
Arthur is linked with a loan move to Arsenal, but he starts here tonight.
Udinese were ordered out of quarantine at the weekend and played in desperate circumstances, losing 6-2 at home to Atalanta.
They have lodged an appeal to have that result scrubbed and the match replayed, as they had so many COVID-19 cases.
The situation remains critical with nine players and three members of staff still testing positive.
To make matters worse, Rodrigo Becao is suspended, while they sold Samir to Watford and Sebastien De Maio to Vicenza over the last few days.
Juventus: Szczesny; Cuadrado, Rugani, De Ligt, Pellegrini; Bentancur, Arthur; McKennie, Dybala, Kulusevski; Kean
Udinese: Padelli; Perez, Nuytinck, Zeegelaar; Soppy, Arslan, Walace, Makengo, Udogie; Deulofeu, Beto