It kicks off at the Allianz Juventus Stadium in Turin at 17.30 UK time (16.30 GMT).
Max Allegri was criticised for resting Chiesa, Dybala and De Ligt for the 1-1 draw with Inter, so they are all back in the starting XI here.
Federico Bernardeschi pulls out after dislocating his shoulder, while Mattia Perin gets a rare run-out in place of Wojciech Szczesny and Adrien Rabiot goes straight into the starting XI now he has shaken off COVID-19.
Juventus: Perin; Danilo, Bonucci, De Ligt, De Sciglio; Chiesa, McKennie, Locatelli, Rabiot; Dybala, Morata
Sassuolo: Consigli: Muldur, Kaan, Ferrari, Rogerio; Maxime Lopez, Frattesi; Berardi, Raspadori, Traorè; Defrel