Federico Chiesa, Manuel Locatelli and Mattia Perin step into the starting XI for Juventus in a must-win game against Fabio Quagliarella’s Sampdoria.
It kicks off at the Allianz Juventus Stadium at 11.30 UK time (10.30 GMT).
You can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
The Old Lady has had a rough start to the season under returning coach Max Allegri, with poor performances and even worse results, just one win and two draws from the opening five rounds.
The comeback to beat Spezia 3-2 midweek hardly boosted confidence by much, so with a Champions League showdown against Chelsea coming up, they need to find form fast.
Perin is brought in to rest Wojciech Szczesny, while Adrien Rabiot joins Giorgio Chiellini, Kaio Jorge and Arthur on the treatment table.
Chiesa and Federico Bernardeschi take the wide roles, with Alvaro Morata returning from the start to partner Paulo Dybala.
Sampdoria are fresh from a 4-0 home defeat to Napoli and continue to miss Manolo Gabbiadini, Valerio Verre, Ronaldo Vieira and Mohamed Ihattaren, who is on loan from Juventus.
Fabio Quagliarella and Francesco Caputo are the front two, with support from Antonio Candreva, Morten Thorsby and Fabio De Paoli, with Mikkel Damsgaard on the bench.
Juventus: Perin; Cuadrado, Bonucci, De Ligt, Alex Sandro; Bernardeschi, Bentancur, Locatelli, Chiesa; Morata, Dybala
Sampdoria: Audero; Bereszynski, Yoshida, Colley, Murru; Candreva, Thorsby, Ekdal, Depaoli; Caputo, Quagliarella