Juventus must rely on Federico Chiesa, Moise Kean and Federico Bernardeschi, while Roma do start Tammy Abraham with Nicolò Zaniolo and Lorenzo Pellegrini despite an ankle sprain.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 UK time (18.45 GMT).
This is a fascinating clash between two of the most historically successful coaches in the division, with Max Allegri and Jose Mourinho both confirming they are happy to focus on results more than aesthetics.
The Bianconeri revived their domestic campaign with three wins in a row going into the break for international duty, but injuries remain a problem.
Paulo Dybala and Matthijs de Ligt are out injured, with Adrien Rabiot testing positive for COVID-19 on international duty with France.
Alvaro Morata is not 100 per cent fit either, so Federico Chiesa becomes a striker with Moise Kean, leaving Federico Bernardeschi and Juan Cuadrado out wide.
Leonardo Bonucci and Giorgio Chiellini are reunited in defence.
Roma were waiting on Abraham, who sprained his ankle while playing for England against Hungary, but the centre-forward has been able to recover sufficiently to start.
Leonardo Spinazzola and Chris Smalling are still out of action, with Pellegrini, Henrikh Mkhitaryan and Zaniolo supporting Abraham.
Juventus: Szczesny; Danilo, Bonucci, Chiellini, De Sciglio; Cuadrado, Bentancur, Locatelli, Bernardeschi; Chiesa, Kean
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Abraham