Juventus look to Paulo Dybala, Alvaro Morata and Dejan Kulusevski in a 4-2-3-1 formation, while Andriy Shevchenko’s Genoa have even more injuries than usual.
It kicks off at 19.45 GMT at the Allianz Juventus Stadium, you can follow all the build-up and action as it happens on the LIVEBLOG.
The Old Lady got back on track midweek by beating Salernitana 2-0, despite a lengthy absentee list that includes Federico Chiesa, Weston McKennie, Danilo, Mattia De Sciglio and Aaron Ramsey.
Mattia Perin has also pulled out, as he was in contact with someone outside the team bubble who tested positive for COVID-19.
Morata returns to the starting XI with Dybala and Kulusevski, while Luca Pellegrini is picked in place of Alex Sandro in a 4-2-3-1 formation.
Giorgio Chiellini is again chosen to partner Matthijs de Ligt, leaving Leonardo Bonucci on the bench for the second game running.
Genoa have one point from their three games under Shevchenko, but are yet to score a single goal during his tenure.
The injury list got even bigger for this game, missing Nicolò Rovella, Stefano Sturaro, Mattia Destro, Felipe Caicedo, Domenico Criscito, Mohamed Fares and Nikola Maksimovic.
It was announced this afternoon that two members of the matchday squad – staff rather than players – tested positive for COVID-19, while Milan Badelj is at home with flu symptoms, but has tested negative.
Flavio Bianchi is picked to lead the attack with Caleb Ekuban.
Juventus: Szczesny; Cuadrado, De Ligt, Chiellini, Pellegrini; Locatelli, Bentancur; Kulusevski, Dybala, Bernardeschi; Morata
Genoa: Sirigu; Biraschi, Bani, Vasquez; Ghiglione, Hernani, Behrami, Toure, Cambiaso; Ekuban, Bianchi