Juventus have Paulo Dybala back in the starting XI with Federico Chiesa and Alvaro Morata, while Atalanta look to Duvan Zapata and Ruslan Malinovskyi.
It kicks off at 17.00 GMT at the Allianz Juventus Stadium in Turin.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Bianconeri are again forced to get back on track under Max Allegri, shaken by the Champions League 4-0 humiliation to Chelsea midweek.
Atalanta didn’t fare much better, fumbling a lead twice and forced to claw back a 3-3 draw away to Young Boys in Berne.
Danilo, Aaron Ramsey and Mattia De Sciglio are still out injured, with Giorgio Chiellini and Federico Bernardeschi only fit for the bench.
Dybala makes his return upfront with Morata, moving Chiesa out wide.
Atalanta have Hans Hateboer back in the squad, but not ready to play yet, while Robin Gosens and Matteo Lovato are sidelined.
Davide Zappacosta sprained his ankle in Switzerland midweek, but is still able to start.
Duvan Zapata leads the attack, this time with support from Malinovskyi and Matteo Pessina.
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; McKennie, Locatelli, Rabiot, Chiesa; Dybala, Morata
Atalanta: Musso; Toloi, Demiral, Djimsiti; Zappacosta, De Roon, Freuler, Maehle; Pessina; Duvan Zapata, Malinovskyi
Lol. It’s so satisfying to see this crook Allegri leads this fake team drowning slowly. Look at your captain, play like a clown. Lol what a Serie B material.