Simone Inzaghi rotates his Inter squad again with Edin Dzeko and Joaquin Correa starting, while Udinese striker Beto is looking for a fourth consecutive match on target.
It kicks off at San Siro at 11.30 GMT, you can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
The Nerazzurri got back on track in the midweek round with a 2-0 victory away to Empoli, despite resting some players.
There is another reshuffle here, with Dzeko and Correa returning to the starting XI, while Stefan de Vrij is among those rested.
Udinese are without Ignacio Pussetto, while Gerard Deulofeu is still not 100 per cent fit.
Isaac Success supports summer signing Beto, who has found the net in each of his last three Serie A appearances.
The Friulani have drawn each of their last four games and have proved surprisingly difficult to break down.
Inter: Handanovic; Skriniar, Ranocchia, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Correa
Udinese: Silvestri; Becao, Nuytinck, Samir; Stryger-Larsen, Pereyra, Jajalo, Makengo, Molina; Success, Beto