Inter make changes with Joaquin Correa partnering Lautaro Martinez and a late Alessandro Bastoni problem against Thiago Motta’s struggling Spezia.
It kicks off at San Siro at 17.30 GMT, you can follow all the build-up and action as it happens from today’s four Serie A games on the LIVEBLOG.
The Nerazzurri are on a roll and closed within one point of second-placed Milan, also beating leaders Napoli 3-1 to blow the Scudetto race wide open.
Matteo Darmian and Andrea Ranocchia join Stefan de Vrij and Aleksandar Kolarov on the treatment table, so Denzel Dumfries and Danilo D’Ambrosio come in.
There is also a late addition to the absentee list, with Alessandro Bastoni suffering from gastroenteritis, decimating the defence.
Nicolò Barella is given a rare rest in midfield and Edin Dzeko goes to the bench, so Tucu Correa partners Lautaro Martinez.
Spezia have Emmanuel Gyasi back from suspension and Daniele Verde has shaken off an injury to bolster the attack, but Medhi Bourabia, Leo Sena and Kevin Agudelo are still out.
It is a special game for former Inter midfielder and current Spezia coach Thiago Motta.
Inter: Handanovic; Skriniar, D’Ambrosio, Dimarco; Dumfries, Gagliardini, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Correa
Spezia: Provedel; Amian, Erlic, Hristov, Kiwior; Reca, Kovalenko, Sala; Gyasi, Salcedo, Manaj