Inter have the opportunity to retake top spot with a victory, but are without Marcelo Brozovic and Alessandro Bastoni against Sassuolo’s Gianluca Scamacca and Giacomo Raspadori.
It kicks off at San Siro at 17.00 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
Serie A Liveblog: Fiorentina-Atalanta, Venezia-Genoa, Inter-Sassuolo, Udinese-Lazio
Milan were held to a 2-2 draw by Salernitana last night, so the Nerazzurri know a win here would allow them to leapfrog to the top spot with a game in hand.
Simone Inzaghi’s men used up a lot of energy in the midweek Champions League loss to Liverpool, while Brozovic and Bastoni sit out bans.
Nicolò Barella was suspended in Europe and returns here, taking on Brozovic’s usual role, with Roberto Gagliardini to plug the gaps.
Joaquin Correa, Robin Gosens and Matias Vecino are injured, while Edin Dzeko is rested in favour of Alexis Sanchez with Lautaro Martinez.
Sassuolo were held 2-2 by Roma last week without Raspadori and Scamacca, but both return from suspension to lead the attack with Domenico Berardi.
Gian Marco Ferrari is banned, with Filip Djuricic, Pedro Obiang and Filippo Romagna injured.
This is a special game for Scamacca and Davide Frattesi, as both have been heavily linked with a potential summer transfer to Inter.
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Darmian, Gagliardini, Barella, Calhanoglu, Perisic; Lautaro Martinez, Alexis Sanchez
Sassuolo: Consigli; Muldur, Ayhan, Chiriches, Kyriakopoulos; Frattesi, Maxime Lopez; Berardi, Raspadori, Traore; Scamacca