Inter launch a new all-Argentine front two of Lautaro Martinez and Tucu Correa, with Denzel Dumfries getting his first start against Marko Arnautovic’s Bologna.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
Simone Inzaghi needs to get his team back on track after a stuttering 2-2 Serie A draw with Sampdoria, followed by the unlucky 1-0 home defeat to Real Madrid in the Champions League.
Edin Dzeko is rested and Stefano Sensi injured, as instead Inter launch a new Argentine partnership of Lautaro Martinez and Joaquin ‘Tucu’ Correa.
Summer signing Dumfries also gets his first start on the right, with Federico Dimarco and Matias Vecino coming into midfield.
Bologna are still unbeaten in Serie A this season with seven points from three rounds, so go into this game on level terms with Scudetto holders Inter.
Jerdy Schouten and Kingsley Michael are on the treatment table, so Nico Dominguez again leads the midfield, with Gary Medel marshalling the defence.
Arnautovic leads the attack with support from Andreas Skov Olsen, Roberto Soriano and Nicola Sansone, dropping Riccardo Orsolini and Musa Barrow.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Brozovic, Vecino, Dimarco; Lautaro Martinez, Correa
Bologna: Skorupski; De Silvestri, Medel, Bonifazi, Hickey; Dominguez, Svanberg; Skov Olsen, Soriano, Sansone; Arnautovic
Ref: Ayroldi