It’s an early potential Scudetto showdown, as Lautaro Martinez, Edin Dzeko and Hakan Calhanoglu face Duvan Zapata, Ruslan Malinovskyi and Robin Gosens.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
Inter have started the season very strong under new coach Simone Inzaghi, despite losing some key players, still unbeaten and dropping points only against Sampdoria.
Meanwhile, Atalanta stuttered to begin with, but are starting to kick into gear and are only three points behind today’s opponents.
Joaquin Correa joins Arturo Vidal, Stefano Sensi and Christian Eriksen on the absentee list, so Lautaro Martinez is again partnered by Edin Dzeko, with support from Hakan Calhanoglu and Matteo Darmian rather than Denzel Dumfries.
Atalanta are still missing Luis Muriel and Hans Hateboer, although it seems the Colombian is recovering faster than expected from a thigh strain.
Davide Zappacosta retains his place on the right, with Gosens on the left, behind Duvan Zapata, Malinovskyi and Matteo Pessina.
Inter: Handanovic; Skriniar, De Vrij, A Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Dzeko
Atalanta: Musso; Toloi, Palomino, Demiral; Zappacosta, Freuler, De Roon, Gosens; Pessina; Malinovskyi, Duvan Zapata