It’s a relegation dogfight between never-say-die Genoa in the debut under their new American owners and a revitalised Hellas Verona under new coach Igor Tudor.
It kicks off at the Stadio Luigi Ferraris at 19.45 UK time (18.45 GMT).
The Grifone completed another comeback in the midweek 2-2 thriller at Bologna, proving they never give up under Davide Ballardini.
Above all, President Enrico Preziosi sold the club after 18 years to American investors 777 Partners, opening up a new era at Marassi.
Felipe Caicedo is still not available, with Stefano Sturaro and Francesco Cassata also carrying injuries, so Mattia Destro again leads the attack with support from Yayah Kallon and Mohamed Fares.
Verona lost their first three games, fired Eusebio Di Francesco, and beat Roma 3-2 on Tudor’s debut.
They had taken a 2-0 lead away to Salernitana midweek with Nikola Kalinic’s brace, only to be pegged back to a 2-2 draw.
Miguel Veloso, Gianluca Frabotta, Bosko Sutalo and Kevin Ruegg remain on the treatment table.
Despite his double midweek, Kalinic is benched with Gianluca Caprari, as Kevin Lasagna and Giovanni Simeone step in.
Genoa: Sirigu; Cambiaso, Biraschi, Maksimovic, Criscito; Badelj, Melegoni; Kallon, Rovella, Fares; Destro
Verona: Montipò; Dawidowicz, Gunter, Casale; Faraoni, Tameze, Ilic, Lazovic; Barak, Lasagna; Simeone