Andriy Shevchenko makes his debut as Genoa coach up against Jose Mourinho’s Roma, as both are forced into changes by injuries and COVID-19.
It kicks off at the Stadio Luigi Ferraris at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
It’s all change at Genoa, as this month the club was sold by Enrico Preziosi to American investors 777 Partners, then Davide Ballardini was fired to bring in Shevchenko for his first club management role after several years in charge of the Ukraine national team.
He’s immediately got a crisis to deal with, Domenico Criscito and Felipe Caicedo joining the already extensive absentee list with Mattia Destro, Mohamed Fares, Nikola Maksimovic, Francesco Cassata, Mattia Bani and Hernani.
Goran Pandev therefore has to lead the way with support from Stefano Sabelli and Caleb Ekuban.
Roma have issues too, losing back-to-back games and struggling badly in recent weeks, with the added bonus of yesterday afternoon finding out Bryan Cristante and Gonzalo Villar have COVID-19.
Leonardo Spinazzola, Matias Vina and Riccardo Calafiori are also injured, so there inevitably have to be adjustments.
Lorenzo Pellegrini is back with Eldor Shomurodov and Stephan El Shaarawy supporting Tammy Abraham, and Mourinho seemingly moves to 4-4-2 with Henrikh Mkhitaryan in midfield.
Genoa: Sirigu; Biraschi, Vasquez, Masiello; Cambiaso, Badelj, Rovella, Sturaro, Sabelli; Pandev, Ekuban
Roma: Rui Patricio; Karsdorp, Kumbulla, Mancini, Ibanez; El Shaarawy, Pellegrini, Veretout, Mkhitaryan; Shomurodov, Abraham