It kicks off at Marassi at 19.45 GMT, you can follow all the build-up and action as it happens from this game and Juventus-Cagliari on the LIVEBLOG.
La Dea need to get back on track after seeing their run of six consecutive Serie A victories ended in spectacular fashion by a 4-1 home defeat to Roma.
Malinovskyi and Miranchuk support Duvan Zapata upfront, a curious decision seeing as Miranchuk has been linked with a January move to Genoa.
Genoa are coming off four Serie A defeats in a row and the arrival of new coach Andriy Shevchenko has done little to improve the situation.
Genoa also announced this evening that a member of staff tested positive for COVID-19.
Genoa: Sirigu; Bani, Vasquez, Criscito; Biraschi, Sturaro, Badelj, Portanova, Cambiaso; Ekuban, Destro
Atalanta: Sportiello; Djimsiti, Demiral, Palomino; Hateboer, Koopmeiners, Freuler, Zappacosta; Miranchuk; Malinovskyi, Duvan Zapata