Empoli look to Leonardo Mancuso and Patrick Cutrone in a battle of the newly-promoted sides with much-changed and troubled Venezia.
It kicks off at the Stadio Castellani at 14.00 UK time (13.00 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Tuscans won the Serie B title last season and are fresh from a shock 1-0 victory at the Allianz Juventus Stadium.
As for Venezia, they’ve lost both games heavily and coach Paolo Zanetti freely admits they are ‘not a team’ yet, having brought in so many new players from all over the world this summer.
Empoli: Vicario; Stojanovic, Ismajli, Luperto, Marchizza; Haas, Ricci, Bandinelli; Bajrami; Mancuso, Cutrone
Venezia: Lezzerini; Mazzocchi, Caldara, Ceccaroni, Schnegg; Vacca, Busio, Fiordilino; Aramu, Henry, Johnsen