It kicks off at 17.00 GMT at the Stadio Castellani.
You can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
The Giallorossi need a victory to climb up the table towards the European spots, but Lorenzo Pellegrini and Leonardo Spinazzola are injured, with Ebrima Darboe and Amadou Diawara at the Africa Cup of Nations.
Jose Mourinho again starts January signings Sergio Oliviera and Maitland-Niles, while Zaniolo and Henrikh Mkhitaryan step back into the starting XI to support Abraham.
Chris Smalling is also back after reportedly catching COVID-19 into a 3-5-2 formation.
Empoli have made a habit of upsetting the bigger clubs, beating the likes of Juventus and Napoli, and pushed Inter to extra time in the Coppa Italia midweek, eventually capitulating 3-2.
Federico Di Francesco, Nicolas Haas and Sebastiano Luperto are not fully fit.
Empoli: Vicario; Fiamozzi, Ismajli, Tonelli, Marchizza; Zurkowski, Ricci, Bandinelli; Bajrami; Henderson, Pinamonti
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Oliveira, Mkhitaryan, Maitland-Niles; Zaniolo, Abraham