Juventus create a new partnership of Dusan Vlahovic and Moise Kean, as they deal with an injury crisis in their trip to Empoli, a side that already beat them this season.
It kicks off at the Stadio Castellani at 17.05 GMT.
Serie A Wk27 Liveblog: Salernitana-Bologna, Empoli-Juventus, Sassuolo-Fiorentina
Juventus have drawn their last four competitive matches with 1-1 results, but the slowdown at the top means a win here would put them within seven points of leaders Milan.
There’s an injury crisis for Max Allegri, who is missing Paulo Dybala, Weston McKennie, Daniele Rugani, Alex Sandro, Giorgio Chiellini, Federico Bernardeschi, Kaio Jorge and Federico Chiesa.
It gives him an opportunity to try a new front three of Juan Cuadrado, Vlahovic and Kean.
Empoli beat Juve in Turin earlier this season, but are currently without a win in nine rounds.
Riccardo Marchizza and Nicolas Haas are out for the rest of the season, but Sebastiano Luperto is back in defence with New Zealand international Liberato Cacace getting his first start.
Nedim Bajrami and Federico Di Francesco support Andrea Pinamonti.
Empoli: Vicario; Stojanovic, Luperto, Ismajli, Cacace; Zurkowski, Asllani, Bandinelli; Di Francesco, Bajrami; Pinamonti
Juventus: Szczesny; Danilo, Bonucci, De Ligt, Pellegrini; Zakaria, Arthur, Rabiot; Cuadrado, Vlahovic, Kean