Atalanta rely on Luis Muriel, Josip Ilicic and Mario Pasalic amid an injury crisis as they visit unpredictable Empoli.
It kicks off at the Stadio Castellani at 14.00 UK time (13.00 GMT).
This is a special day for Atalanta, the 114th anniversary of the club’s foundation.
La Dea have stuttered so far this season and were beaten 3-2 at home by Milan before the break for international duty.
The injuries are piling up for Gian Piero Gasperini, especially ahead of a Champions League showdown with Manchester United, as Robin Gosens, Matteo Pessina, Hans Hateboer and Berat Djimsiti are all out of action for over a month.
Muriel therefore leads the way with support from Ilicic and Pasalic, with Joakim Maehle and Davide Zappacosta as the wing-backs.
Rafael Toloi returns from injury too, to bolster the defence, and Teun Koopmeiners gets a rare start.
Empoli are capable of beating Juventus, Bologna and Cagliari, but also lost at home to Venezia and Sampdoria, so are deeply unpredictable.
Andrea Pinamonti has shaken off a knock to start upfront with Federico Di Francesco and Liam Henderson preferred to Nedim Bajrami.
Empoli: Vicario; Stojanovic, Romagnoli, Viti, Marchizza; Haas, Stulac, Zurkowski; Henderson; Di Francesco, Pinamonti
Atalanta: Musso; Toloi, Demiral, Palomino; Zappacosta, De Roon, Koopmeiners, Maehle; Pasalic; Ilicic, Muriel