Jose Mourinho uses the same starting XI yet again as Roma visit Cagliari, who miss Kevin Strootman and Nahitan Nandez.
It kicks off at the Sardegna Arena at 19.45 UK time (18.45 GMT).
The Giallorossi are still dealing with the aftermath of their 6-1 Conference League defeat to Bodo/Glimt.
Ever since claiming he has ‘only 13 players,’ Mourinho has used the same starting XI, not even calling up outcasts Borja Mayoral, Amadou Diawara, Gonzalo Villar and Bryan Reynolds.
At least Marash Kumbulla is back on the bench this time, but Leonardo Spinazzola and Chris Smalling are injured.
Mourinho is in the stands, as he was sent off for dissent and given a touchline ban after the draw with Napoli.
Cagliari have barely improved since Walter Mazzarri took over from Leonardo Semplici, following the 3-1 win over Sampdoria with a 3-0 defeat at Fiorentina.
The injuries are piling up, as Diego Godin, Nahitan Nandez and ex-Roma midfielder Kevin Strootman are added to the absentee list.
They join Martin Caceres, Damir Ceter, Marko Rog, Dalbert and Sebastian Walukiewicz on the treatment table.
Leonardo Pavoletti is chosen to partner Joao Pedro upfront rather than Keita Balde Diao.
Cagliari: Cragno; Zappa, Ceppitelli, Carboni, Lykogiannis; Bellanova, Marin, Grassi, Deiola; Joao Pedro, Pavoletti
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez; Vina, Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Abraham