Genoa and Cagliari both start new signings, as Keita Balde Diao and Nikola Maksimovic slot straight into the starting XI.
It kicks off at the Sardegna Arena at 14.00 UK time (13.00 GMT).
You can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
The Sardinians opened the campaign with a 2-2 home draw against Spezia and 4-1 defeat to Milan.
While Alessio Cragno is back in goal, Diego Godin and Kevin Strootman are carrying knocks, plus Nahitan Nandez rested after international duty.
Genoa lost both opening fixtures to Inter and Napoli, so hope the calendar can be a bit kinder from now on.
Felipe Caicedo, Mohamed Fares and Johan Vasquez arrived on deadline day, but aren’t ready to start, yet Nikola Maksimovic is pushed straight into the back three.
Cagliari: Cragno; Walukiewicz, Ceppitelli, Carboni; Zappa, Marin, Deiola, Grassi, Dalbert; Joao Pedro, Keita
Genoa: Sirigu; Biraschi, Maksimovic, Criscito; Sabelli, Sturaro, Rovella, Toure, Cambiaso; Pandev, Destro