Roma have Bryan Cristante back in the squad after COVID-19, as Tammy Abraham and Nicolò Zaniolo lead the way against Marko Arnautovic’s Bologna.
It kicks off at the Stadio Dall’Ara at 17.30 GMT.
The Giallorossi got back on track under Jose Mourinho last week with wins in the Europa League and domestically, beating Torino.
There was mixed news from the treatment room, as while Cristante is available again after testing negative for COVID-19 yesterday, they have lost teenage sensation Felix Afena-Gyan and Gonzalo Villar to the same virus.
Jordan Veretout returns from suspension, while Lorenzo Pellegrini is out until the New Year with a muscle strain.
Bologna are finding some consistency now since the switch to three at the back under coach Sinisa Mihajlovic.
Jerdy Schouten and Ibrahima Mbaye are injured, but Lorenzo De Silvestri returns after his sprain.
Bologna: Skorupski, Soumaoro, Medel, Theate; Skov-Olsen, Svanberg, Dominguez, Hickey; Soriano, Barrow; Arnautovic
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Veretout, Diawara, Mkhitaryan, El Shaarawy; Zaniolo, Abraham