Ciro Immobile is out injured, so Vedat Muriqi starts in Lazio’s attack with Pedro and Felipe Anderson.
It kicks off at the Stadio Dall’Ara at 11.30 UK time (10.30 GMT).
You can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
The Aquile have finally found some form after a stuttering start to the season under Sarri, fresh from a 3-2 Derby della Capitale victory against Roma and Europa League win over Lokomotiv Moscow.
Immobile limped off in that match and has been ruled out of the upcoming Nations League tournament too.
With both Immobile and Mattia Zaccagni injured, Sarri picks his natural replacement Muriqi, flanked by Felipe Anderson and Pedro.
Adam Marusic again gets the nod at right-back rather than Manuel Lazzari, with Luis Alberto, Sergej Milinkovic-Savic and Lucas Leiva in midfield.
Bologna are in crisis after one point from the last three games, which included a 6-1 defeat to Inter and 4-2 loss at Empoli.
Jerdy Schouten and Nicola Sansone are out of action, but Adama Soumaoro is available, as his COVID test proved to be a false positive.
Marko Arnautovic again leads the way, with support from Roberto Soriano and Musa Barrow.
However, there’s a switch of tactics to three at the back, moving Aaron Hickey into a more advanced role.
Bologna: Skorupski; Medel, Soumaoro, Theate; De Silvestri, Dominguez, Svanberg, Hickey; Soriano, Barrow; Arnautovic.
Bench: Bardi, Bagnolini, Binks, Bonifazi, Orsolini, Sansone, Olsen, Mbaye, Santander, Van Hoojidonk, Vignato, Cangiano.
Lazio: Reina; Marusic, Luiz Felipe, Acerbi, Hysaj; Milinkovic-Savic, Leiva, Luis Alberto; Felipe Anderson, Pedro, Muriqi.
Bench: Strakosha, Adamonis, Gabarron, Escalante, Akpa Akpro, Romero, Radu, Raul Moro, Andre Anderson, Lazzari, Cataldi, Basic.