Cremonese stunned Napoli in the Coppa Italia midweek on Davide Ballardini’s debut and hope for their first Serie A win of the season against Bologna.
It kicks off at the Stadio Dall’Ara at 17.30 GMT.
Thiago Motta’s Bologna are relatively comfortable mid-table, but also go into this game decimated by injuries.
They are still missing star striker Marko Arnautovic, Kevin Bonifazi, Gary Medel and Lorenzo De Silvestri, now joined also by Nicola Sansone on the treatment table.
It leaves Musa Barrow as the only real option upfront, with Joshua Zirkzee fit for the bench.
Cremonese knocked Napoli out of the Coppa Italia midweek on penalties after a thrilling 2-2 draw at the Stadio Diego Armando Maradona.
That was the debut of new coach Ballardini, replacing sacked Massimiliano Alvini, and he hopes to get their first Serie A victory of the season now too.
Christian Acella is out of action, but Vlad Chiriches returns and new signing Marco Benassi is on the bench after his arrival on loan from Fiorentina.
Bologna: Skorupski; Posch, Soumaoro, Lucumi, Lykogiannis; Moro; Orsolini, Dominguez, Ferguson, Soriano; Barrow
Cremonese: Carnesecchi; Ferrari, Chiriches, Vasquez; Sernicola, Pickel, Castagnetti, Meite, Valeri; Ciofani, Okereke