Atalanta are by no means playing well at the moment, but they have Marten de Roon back and start Teun Koopmeiners against Domenico Berardi’s Sassuolo.
It kicks off at the Gewiss Stadium in Bergamo at 19.45 UK time (18.45 GMT).
La Dea are ploughing on despite some less than stellar performances, scraping a 1-0 win away to Salernitana at the weekend.
The good news for Gian Piero Gasperini is that De Roon has finally completed his four-match ban and can start in midfield.
Luis Muriel and Hans Hateboer are still ruled out, so Duvan Zapata gets no rest upfront.
Koopmeiners gets his first start in the Atalanta jersey.
Sassuolo haven’t done that well either since Alessio Dionisi replaced Roberto De Zerbi on the bench, picking up four points from three rounds and beaten at home by Torino last time.
Gregoire Defrel takes over as centre-forward from Giacomo Raspadori, with Pedro Obiang and Filippo Romagna on the treatment table.
There’s some squad rotation, with Davide Frattesi and Mert Muldur brought in.
Atalanta: Musso; Djimsiti, Demiral, Toloi; Zappacosta, Koopmeiners, De Roon, Gosens; Pessina; Malinovskyi, Duvan Zapata
Sassuolo: Consigli; Muldur, Ayhan, Ferrari, Kyriakopoulos; Magnanelli, Frattesi; Berardi, Traore, Boga; Defrel