Atalanta are looking for a seventh consecutive Serie A victory with Duvan Zapata and Mario Pasalic, while Jose Mourinho has Nicolò Zaniolo back with Tammy Abraham for Roma.
It kicks off at the Gewiss Stadium at 14.00 GMT.
You can follow all the build-up and action as it happens from this game, Bologna-Juventus and Cagliari-Udinese on the LIVEBLOG.
There was a bit of a worry this morning, as at 10.30 GMT an earthquake measuring 4.4 on the Richter scale with the epicentre in Bergamo was registered, but there seems to be no damage to buildings.
This is a big game for their respective ambitions, as Atalanta can make the most of the Milan-Napoli showdown by potentially taking second place and Roma need to avoid falling further behind in the race for European spots.
La Dea are on 99 at the moment, so could become the fourth club to score 100 Serie A goals in a single calendar year.
Inter already hit that mark last night, the first side to achieve it since 1950.
Robin Gosens is the only absentee for Gian Piero Gasperini, as Malinovskyi and Duvan Zapata lead the way upfront with support from Matteo Pessina.
Roma have Felix Afena-Gyan suspended, with Stephan El Shaarawy, Lorenzo Pellegrini, Leonardo Spinazzola and Carles Perez out of action.
The good news is that Zaniolo and Gianluca Mancini return from suspension, but Roger Ibanez is not at 100 per cent, so Marash Kumbulla gets a rare start in defence.
Atalanta were meant to be wearing their special edition Christmas jersey, but it was scrapped after complaints the skyline of Bergamo looked more like Turin.
Atalanta: Musso; Toloi, Palomino, Djimsiti; Hateboer, De Roon, Freuler, Pezzella; Ilicic; Pasalic, Zapata
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Veretout, Cristante, Zaniolo, Vina; Mkhitaryan; Abraham
Finally us Roma fans can celebrate a win against a top serie A side ✊