It’s a Lombardy Derby, potential Scudetto showdown and battle between the two most prolific sides in Serie A, as Luis Muriel and Matteo Pessina take on Edin Dzeko and Alexis Sanchez.
It kicks off at the Gewiss Stadium in Bergamo at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
Atalanta are on sparkling form and fresh from a 6-2 victory away to Udinese.
Joakim Maehle joined Duvan Zapata, Rafael Toloi and Robin Gosens on the treatment table, but Remo Freuler is back after suspension.
Muriel therefore leads the attack with support from Matteo Pessina and Mario Pasalic.
There were reports Josip Ilicic would start, but he is not even on the bench and neither is Ruslan Malinovskyi, suggesting they are the players who tested positive for COVID-19 this week.
Inter were pushed to extra time on Wednesday, beating Juventus in the final seconds with substitute Alexis Sanchez to win the Supercoppa Italiana 2-1.
The Chilean impressed so much that he has earned a starting spot here in place of Lautaro Martinez, partnering Dzeko.
Danilo D’Ambrosio gets the nod rather than Stefan de Vrij in defence.
Hakan Calhanoglu missed last week’s Serie A victory over Lazio through suspension and returns to the midfield here, as Inter seek a ninth straight win in the League.
Atalanta have not beaten Inter since a 4-1 result here in November 2018, managing four draws and two defeats.
Atalanta: Musso; Djimsiti, Demiral, Palomino; De Roon, Freuler, Koopmeiners, Pezzella; Pasalic, Pessina; Muriel
Inter: Handanovic; D’Ambrosio, Skriniar, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Alexis Sanchez, Dzeko