Napoli give Kim Min-jae and Kvicha Kvaratskhelia their debuts with Victor Osimhen and Hirving Lozano, while Verona look to Kevin Lasagna and Thomas Henry.
It kicks off at the Stadio Bentegodi at 17.30 UK time (16.30 GMT).
The Partenopei have a traditional rivalry with Hellas, which makes the move of Giovanni Simeone to Napoli particularly unusual, but he is not in the squad facing his former teammates.
Fabian Ruiz is left out ahead of his transfer to PSG, with Matteo Politano only fit for the bench and Gianluca Gaetano suspended.
It’s an exciting front three of Lozano, Osimhen and Georgia international Kvaratskhelia, with South Korea international Kim Min-jae in defence.
Verona have Miguel Veloso and Federico Ceccherini sitting out bans, but look to Thomas Henry and Kevin Lasagna upfront under new coach Gabriele Cioffi.
Hellas will wear special jerseys to mark the death of Scudetto-winning goalkeeper Claudio Garella.
Verona: Montipò; Dawidowicz, Gunter, Amione; Faraoni, Tameze, Hongla, Ilic, Lazovic; Henry, Lasagna
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia
I realy like victor and napoli and i want to be there fans