Roma have the opportunity to close on the top four, so Tommaso Baldanzi and Romelu Lukaku start for the trip to relegation-threatened Udinese.
It kicks off at the Bluenergy Stadium at 17.00 UK time (16.00 GMT).
The Giallorossi are still fired up following back-to-back 1-0 victories decided by Gianluca Mancini headers, first in the derby with Lazio, then the Europa League quarter-final away to Milan.
The second leg of that tie is on Thursday, but there is relatively little squad rotation, because Daniele De Rossi also has the chance to close up on the top four after Juventus and Bologna stalemates.
Sardar Azmoun is the only remaining injury absentee, but Lukaku continues to lead the attack with Paulo Dybala rested.
Bryan Cristante will be suspended against Milan, so he starts, while Evan Ndicka returns in defence after he missed the first leg due to a ban.
It would appear to be a 3-5-2 formation, but that remains to be seen.
Udinese are at serious risk of relegation, sitting just two points clear of the drop zone going into this weekend.
As always, it’s a long injury list including Sandi Lovric, Florian Thauvin, Keinan Davis, Enzo Ebosse and Gerard Deulofeu.
Lorenzo Lucca returns from suspension with Lazar Samardzic hoping to rediscover some form in midfield.
Udinese: Okoye; Perez, Bijol, Kristensen; Ehizibue, Walace, Samardzic, Payero, Kamara; Pereyra; Lucca
Roma: Svilar; Huijsen, Llorente, Ndicka; Zalewski, Cristante, Paredes, Aouar, Angelino; Baldanzi, Lukaku
Player statistic
| Roberto Pereyra |  |
24' | ||
| Hassane Kamara |  |
31' |
| Jaka Bijol | |
58' | ||
| 64' | |
Romelu Lukaku (Assist: Bryan Cristante) | ||
| Martín Payero | |
66' | ||
| 69' | |
Tommaso Baldanzi | ||
| 90+3' | |
Rick Karsdorp | ||
| 90+5' | |
Bryan Cristante (Assist: Paulo Dybala) |
Match statistic
