Roma aim for the Serie A leadership with Leonardo Spinazzola returning to support Paulo Dybala and Tammy Abraham against Gerard Deulofeu and Udinese.
It kicks off at the Dacia Arena in Udine at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Giallorossi went into this weekend joint top with Atalanta on 10 points, but Jose Mourinho has more injury problems to deal with.
Stephan El Shaarawy and Marash Kumbulla have been added to the absentee list, with Nicolò Zaniolo, Georginio Wijnaldum and Ebrima Darboe.
Spinazzola and Rick Karsdorp return after they were rested, helping Dybala and Lorenzo Pellegrini support Abraham, with Andrea Belotti on the bench.
Udinese are fresh from a victory over Fiorentina, but saw Adam Masina stretchered off to join Buta on the treatment table.
Isaac Success and Deulofeu lead the way, with Roberto Pereyra in midfield and future Tottenham Hotspur wing-back Destiny Udogie, as Beto is rested.
Udinese: Silvestri; Becao, Bijol, Perez; Pereyra, Samardzic, Walace, Arslan, Udogie; Deulofeu, Success
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Matic, Cristante, Spinazzola; Dybala, Pellegrini; Abraham