The pressure is piling on Inter after their midweek capitulation and they visit giant-killers Udinese with Samir Handanovic returning in goal, but Hakan Calhanoglu suspended.
It kicks off at the Dacia Arena at 17.00 UK time (16.00 GMT).
Serie A Liveblog: Juventus-Venezia, Milan-Fiorentina, Udinese-Inter, Roma-Bologna
The Scudetto race was shaken up on Wednesday when Inter lost their game in hand 2-1 away to Bologna, thanks to a Ionut Radu howler.
That was his first Serie A appearance of the season, only the second in all competition, and inevitably he was rusty when rushed in to replace Handanovic due to a back issue.
The veteran goalkeeper is still not fully fit, but grits his teeth to start anyway in Udine.
Calhanoglu is suspended, with Alessandro Bastoni injured, but Arturo Vidal is only on the bench, so Roberto Gagliardini starts behind Lautaro Martinez and Edin Dzeko.
Milan beat Fiorentina 1-0 this afternoon, so temporarily went five points clear.
Udinese also played their rescheduled Week 20 game midweek, a surprise 4-0 victory away to Fiorentina, so they are brimming with confidence.
Norberto Beto is still out injured and Jean-Victor Makengo suspended, with Roberto Pereyra back, so Isaac Success again partners Gerard Deulofeu.
Udinese: Silvestri; Becao, Pablo Marì, Perez; Molina, Arslan, Walace, Pereyra, Udogie; Deulofeu, Success
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Darmian, Barella, Brozovic, Gagliardini, Perisic; Lautaro Martinez, Dzeko