Udinese are the surprise of the season so far and hope to cause another upset with Beto and Gerard Deulofeu against Lautaro Martinez’s Inter, who must do without Hakan Calhanoglu.
It kicks off at the Dacia Arena at 11.30 UK time (10.30 GMT).
The Friulani are currently one point above Inter in the Serie A table thanks to four wins on the bounce, including a 4-0 thrashing of Roma.
Adam Masina is out with a torn anterior cruciate ligament, but everyone else is available for coach Andrea Sottil, who starts with Beto and Deulofeu upfront, plus Destiny Udogie on the wing.
Inter got back on track in the Champions League by beating Viktoria Plzen, but Romelu Lukaku is still out of action and is joined by Calhanoglu.
Henrikh Mkhitaryan gets the nod rather than Roberto Gagliardini in midfield, with Edin Dzeko partnering Lautaro Martinez.
Samir Handanovic returns in goal, as Andre Onana seems to be preferred in the Champions League.
Francesco Acerbi also starts again rather than Stefan de Vrij after his debut midweek.
The Nerazzurri are unbeaten away to Udinese in Serie A since a 3-0 result in January 2013.
Udinese: Silvestri; Perez, Becao, Bijol; Pereyra, Lovric, Walace, Makengo, Udogie; Deulofeu, Beto
Inter: Handanovic; Skriniar, Acerbi, Bastoni; Dumfries, Barella, Brozovic, Mkhitaryan, Darmian; Lautaro Martinez, Dzeko