Andrea Belotti faces his former club for Fiorentina with Lucas Beltran and Nico Gonzalez, while Torino have Alessandro Buongiorno back with Duvan Zapata upfront.
It kicks off at the Stadio Olimpico Grande Torino at 19.45 GMT.
This is a head-to-head for European ambitions, as the Viola go into the weekend in seventh place, five points ahead of Torino in 10th.
Fiorentina are very unpredictable, crushing Frosinone 5-1, then losing to Bologna 2-0, drawing with Empoli and beating Lazio 2-1.
Lucas Martinez-Quarta and Christian Kouame were both hospitalised last week, with kidney stones and malaria respectively, so are out of action along with Gaetano Castrovilli and Oliver Christensen.
Dodo is back on the bench after six months out with a torn anterior cruciate ligament.
This is a special match for Belotti, who was the captain of Torino before leaving as a free agent for Roma and joined Fiorentina on loan in January.
Vincenzo Italiano is also preparing for the Conference League Round of 16 tie against Maccabi Haifa on Thursday.
Tension is sky high behind the scenes at Toro, where coach Ivan Juric and President Urbano Cairo are at loggerheads, so a new contract seems improbable.
Their European hopes took a tumble following back-to-back defeats with Lazio and Roma.
Mergim Vojvoda, Adrien Tameze, Matteo Lovato and Perr Schuurs are injured, but the big news is the return of defender Buongiorno after dislocating his shoulder on January 26.
Duvan Zapata and Antonio Sanabria continue to lead the way upfront.
Torino: Milinkovic-Savic; Djidji, Buongiorno, Masina; Bellanova, Linetty, Ilic, Rodriguez; Vlasic; Zapata, Sanabria
Fiorentina: Terracciano; Kayode, Milenkovic, Ranieri, Biraghi; Arthur, Bonaventura; Nico Gonzalez, Beltran, Sottil; Belotti
Player statistic
| 7' |  |
Luca Ranieri | ||
| 41' | |
Lucas Beltrán | ||
| Samuele Ricci | |
45+5' | ||
| Samuele Ricci |  |
45+7' | ||
| 45+7' | |
Arthur Melo |
| 83' | |
Antonin Barak |
Match statistic
