Napoli hope to take another step towards the Scudetto with Victor Osimhen and Kvicha Kvaratskhelia, as decimated Spezia give Eldor Shomurodov his debut.
It kicks off at the Stadio Alberto Picco at 11.30 GMT.
The Partenopei are already 13 points clear at the top of the table, and with Inter–Milan this evening it’s an opportunity to extend that advantage even further.
Luciano Spalletti has a full squad to choose from and looks to Chucky Lozano with Osimhen and Kvaratskhelia upfront.
The same cannot be said for Spezia, who are missing nine players, including suspended Emanuel Gyasi, injured M’Bala Nzola, Simone Bastoni, Emil Holm, Albin Ekdal, Joao Moutinho, Szymon Zurkowski, Jeroen Zoet, Jacopo Sala and Viktor Kovalenko.
Even coach Luca Gotti is on the treatment table after hip surgery for mobility issues earlier this week.
Shomurodov, on loan from Roma, is therefore thrown straight into the starting XI for his debut.
Spezia: Dragowski; Ampadu, Caldara, Nikolaou; Amian, Bourabia, Esposito, Agudelo, Reca; Verde, Shomurodov
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia