Juventus turn to Moise Kean and Dusan Vlahovic for the visit to managerless Spezia, who start Daniele Verde and Eldor Shomurodov upfront.
It kicks off at the Stadio Picco at 17.00 GMT.
The Bianconeri were held to a disappointing and contentious 1-1 draw by FC Nantes in the Europa League play-off on Thursday, when a last-gasp penalty appeal was rejected after a VAR review.
With the second leg coming up, Max Allegri decides to rotate the squad, as Federico Chiesa, Arkadiusz Milik, Fabio Miretti, Paul Pogba and Kaio Jorge are all out of action.
Gleison Bremer sits out a ban, so Daniele Rugani starts in defence, with Nicolò Fagioli not 100 per cent fit and Wojciech Szczesny rested.
That means a front two of Vlahovic and Kean, with Mattia Perin in goal.
Spezia sacked coach Luca Gotti on Wednesday and have chosen Leonardo Semplici as his replacement, but the contract is not yet finalised, so Fabrizio Lorieri is the interim manager today.
He is without suspended Salvatore Esposito, but Ethan Ampadu and Mattia Caldara return from their bans.
Simone Bastoni, Szymon Zurkowski, Jacopo Sala, Joao Moutinho and Jeroen Zoet are still out of action.
Spezia: Dragowski; Ampadu, Amian, Nikolaou; Gyasi, Bourabia, Ekdal, Agudelo, Reca; Verde, Shomurodov
Juventus: Perin; Danilo, Rugani, Alex Sandro; Cuadrado, Locatelli, Paredes, Rabiot, Kostic; Di Vlahovic, Kean
Player statistic
| 1' |  |
Manuel Locatelli | ||
| Kevin Agudelo | |
16' | ||
| 32' |  |
Moise Kean (Assist: Filip Kostic) |
| 51' | |
Nicolò Fagioli | ||
| Arkadiusz Reca | |
55' | ||
| 66' | |
Ángel Di María (Assist: Danilo) |
Match statistic
