Milan give Simon Kjaer his first start in nine months and make other changes for the trip to Domenico Berardi’s Sassuolo.
It kicks off at 17.30 UK time (16.30 GMT).
The Rossoneri are unbeaten and joint top of the table on seven points, as after three rounds nobody still has a 100 per cent record.
With the Milan Derby coming up this weekend, Stefano Pioli rotates the squad, giving Kjaer his first start since rupturing his anterior cruciate ligament nine months ago.
Ante Rebic and Divock Origi are added to the injury list, joining Rade Krunic and Zlatan Ibrahimovic.
Sassuolo lost badly in the opening game with Juventus, but have since steadied the ship with a win over Lecce and 2-2 draw at Spezia.
Having sold Giacomo Raspadori and Gianluca Scamacca this summer, Berardi becomes ever-more important.
Hamed Junior Traore and Mert Muldur are still long-term injury absentees.
Sassuolo: Consigli; Toljan, Erlic, Ferrari, Rogerio; Frattesi, Maxime Lopez, Thorsvedt; Berardi, Pinamonti, Kyriakopoulos
Milan: Maignan; Florenzi, Kjaer, Tomori, Theo Hernandez; Pobega, Bennacer; Saelemaekers, Brahim Diaz, Leao; Giroud