The Milan injury crisis continues to grow with Divock Origi also absent for this trip to Sampdoria.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Luigi Ferraris, also known as Marassi.
Origi had been tipped to get his first start here, but instead has not made the journey to Genoa at all due to yet another muscular problem.
He joins Alessandro Florenzi, Ante Rebic, Rade Krunic and Zlatan Ibrahimovic on the treatment table.
It means Olivier Giroud gets no rest after the midweek Champions League draw with RB Salzburg, but Simon Kjaer and Tommaso Pobega step in.
Sampdoria have already held Juventus and Lazio to draws in this stadium, despite struggling to score goals.
Omar Colley and Harry Winks are out of action, while Jeison Murillo and Alex Ferrari have recovered.
Sampdoria: Audero; Bereszynski, Ferrari, Murillo, Augello; Villar, Rincon, Leris; Sabiri, Djuricic; Caputo
Milan: Maignan; Calabria, Kjaer, Kalulu, Theo Hernandez; Pobega, Tonali; Messias, De Ketelaere, Leao; Giroud