Luis Alberto steps into the starting XI with Ciro Immobile as Lazio aim to build momentum against Sampdoria, who look to Fabio Quagliarella to break their goal drought.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 17.30 UK time (16.30 GMT).
The Biancocelesti are fresh off their 3-1 victory against Inter, including a stunning Luis Alberto goal off the bench.
He earns himself a place in the starting XI, though Pedro is struggling with an ankle knock and Francesco Acerbi remains frozen out pending a transfer.
Sampdoria have been very unlucky so far this season, failing to score a single goal, but rattling the woodwork numerous times.
After their 0-0 draw with Juventus, veteran Quagliarella is brought into the line-up with Valerio Verre and Abdelhamid Sabiri.
Sampdoria: Audero; Bereszynski, Murillo, Colley, Augello; Rincon, Vieira; Verre, Sabiri, Leris; Quagliarella
Lazio: Provedel; Lazzari, Patric, Romagnoli, Marusic; Milinkovic-Savic, Cataldi, Luis Alberto; Felipe Anderson, Immobile, Zaccagni