Inter bring back the LuLa strike partnership with Romelu Lukaku and Lautaro Martinez, while Sampdoria rely on Manolo Gabbiadini and have new signing Jese Rodriguez on the bench.
It kicks off at the Stadio Luigi Ferraris at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri need a win here to avoid Napoli extending their lead at the top of the table, which after last night’s victory over Cremonese has temporarily moved to 16 points.
Simone Inzaghi still does not start midfielder Marcelo Brozovic, but we do see the return of the LuLa strike partnership for the first time from the start in 2023.
Only Joaquin Correa is on the treatment table.
Check the live statistics from the match here.
Sampdoria remain rooted in the bottom two and are still seething after conceding a last-gasp equaliser to Monza, but at least it ended their run of four consecutive defeats.
Medhi Leris is suspended, so Alessandro Zanoli steps in, with Harry Winks and Gabbiadini providing the experience and quality.
Koray Gunter, Ignacio Pussetto and Andrea Conti are injured, while Omar Colley was sold.
It’s a special game for Dejan Stankovic, who won the Treble at Inter and was Inzaghi’s teammate at Lazio.
Sampdoria: Audero; Murillo, Nuytinck, Amione; Zanoli, Cuisance, Winks, Augello; Djuricic; Gabbiadini, Lammers
Inter: Onana; Skriniar, De Vrij, Acerbi; Darmian, Barella, Calhanoglu, Mkhitaryan, Gosens; Lautaro Martinez, Lukaku