The Derby della Lanterna is also a desperate relegation dogfight, as both Sampdoria and Genoa risk going down, so there’s everything at stake this evening.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 17.00 UK time (16.00 GMT).
Serie A Liveblog: Napoli-Sassuolo, Cagliari-Verona, Sampdoria-Genoa, Spezia-Lazio
Recent results have blown the race for safety wide open, as Samp are in 16th place on 30 points, followed by Cagliari on 28, Salernitana and Genoa 25 and Venezia 22.
It’s also worth noting that Salernitana and Venezia will go head-to-head next week, as they both have that game in hand.
Tomas Rincon is suspended for Sampdoria, with Sebastian Giovinco and Manolo Gabbiadini injured.
Stefano Sensi and Abdelhamid Sabiri support Francesco Caputo, with Fabio Quagliarella on the bench.
Genoa are without Nikola Maksimovic, Andrea Cambiaso, Nicolò Rovella, Roberto Piccoli and Zinho Vanheusden.
Sampdoria: Audero; Bereszynski, Ferrari, Colley, Augello; Candreva, Ekdal, Thorsby, Sabiri; Sensi; Caputo
Genoa: Sirigu; Frendrup, Ostigard, Bani, Vasquez; Sturaro, Badelj; Galdames, Amiri, Ekuban; Destro