Jose Mourinho unleashes the new Roma with Paulo Dybala Tammy Abraham and Nicolò Zaniolo together, as Salernitana debut Tonny Vilhena and Antonio Candreva.
It kicks off at the Stadio Arechi at 19.45 UK time (18.45 GMT).
The Giallorossi boosted their squad this summer with the arrival of free agents Dybala and Nemanja Matic, but La Joya starts evening with Abraham, Zaniolo and Lorenzo Pellegrini.
Salernitana scraped Serie A safety on the final day of the season after fighting back from a seemingly impossible situation and have stuck with coach Davide Nicola.
He is throwing new signings Candreva and Vilhena straight into the starting XI for their debuts, while Emiliano Bonazzoli leads the attack.
Matteo Lovato and Emil Bohinen are both out of action for at least a couple of months.
Salernitana: Sepe; Gyomber, Fazio, Bronn; Candreva, Kastanos, L Coulibaly, Vilhena, Mazzocchi; Botheim, Bonazzoli
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Pellegrini, Cristante, Spinazzola; Dybala, Zaniolo; Abraham